Author(s): Frazer DG, Jones WG, Petsonk EL, Kullman GJ, Barger MW, , Frazer DG, Jones WG, Petsonk EL, Kullman GJ, Barger MW,
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Abstract The objective of this investigation was to elucidate the pulmonary responses of an animal model to dust generated from leaf/wood compost which had caused a severe case of acute respiratory illness in an individual. Guinea pigs were exposed for 4 hr to 30 mg/m3 of aerosolized leaf/wood compost dust. Inhalation resulted in significant cellular activation and changes in pulmonary mechanics. Maximal elevation in breathing rate (increases 36\%) was observed 12-18 hr postexposure. Similarly, maximal granulocyte infiltration (increases 1,600\%) and activation of alveolar macrophages (increases 65\%) occurred 18 hr postexposure. In contrast, maximal airway obstruction (increases 120\%) occurred immediately after exposure and returned toward normal (increases 53\%) by 18 hr postexposure. In several respects, the airway obstruction and pulmonary inflammation described in the animal model were comparable to the human response to compost dust. Therefore, this animal model may be useful in predicting the potential respiratory hazard associated with exposure to various organic dusts.
This article was published in Am J Ind Med
and referenced in Journal of Drug Metabolism & Toxicology