alexa Organizing Pneumonia Induced by Nivolumab in a Patient with Metastatic Melanoma
Medicine

Medicine

Internal Medicine: Open Access

Author(s): Kazuhisa Nakashima, Tateaki Naito, Shota Omori, Shusuke Yoshikawa, Masahiro Endo

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A 70-year-old woman with a 7-month history of recurrent postoperative malignant melanoma with pulmonary metastases (Fig. 1A) presented with fever, anorexia, exertional dyspnea, and productive cough. The patient had never smoked and had no underlying pulmonary disease. Eleven weeks before presentation, she enrolled in a clinical trial of nivolumab, an anti–programmed death 1 monoclonal antibody, during which she received four doses of nivolumab (2 mg/kg every 3 weeks). Computed tomography of the chest revealed multiple ground-glass opacities surrounded by consolidations of air bronchograms in the lower lung fields (reversed halo sign, Fig. 1B).

This article was published in Journal of Thoracic Oncology and referenced in Internal Medicine: Open Access

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