alexa Organ-specific features of natural killer cells.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Shi FD, Ljunggren HG, La Cava A, Van Kaer L

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Abstract Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical. Here, we examine the divergent phenotypic and functional features of NK cells, as deduced largely from experimental mouse models of pathophysiological responses in the liver, mucosal tissues, uterus, pancreas, joints and brain. Moreover, we discuss how organ-specific factors, the local microenvironment and unique cellular interactions may influence the organ-specific properties of NK cells.
This article was published in Nat Rev Immunol and referenced in Journal of Vaccines & Vaccination

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