alexa Origins of epilepsy in fragile X syndrome.
Neurology

Neurology

Brain Disorders & Therapy

Author(s): Hagerman PJ, Stafstrom CE

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Abstract Fragile X syndrome is the leading heritable form of cognitive impairment and the leading known monogenic disorder associated with autism. Roughly one-quarter of children with this disorder have seizures, most of which are relatively benign and are resolved beyond childhood. Because of the prevalence of fragile X syndrome, numerous animal models have been developed and electrophysiological studies have taken place to investigate its pathogenesis. The investigations have yielded a wealth of information regarding the synaptic dysfunction that underlies the hyperexcitability and epileptiform features associated with this disorder.
This article was published in Epilepsy Curr and referenced in Brain Disorders & Therapy

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