alexa Oseltamivir boosts 2009 H1N1 virus infectivity in vitro.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Lin X, Zhou J, Zhang Y, Wu J, Zhang F,

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Abstract The neuraminidase inhibitor oseltamivir has been identified to have significant anti-influenza activity in clinical practice. However, its efficacy has not been verified in enough subtypes of influenza A virus, particularly, the current pandemic virus, H1N1. In vitro, using our influenza pseudotyped particle system, oseltamivir displayed significant inhibitory effects on viral NA activity and pp release. Conversely, a boosting effect on viral infection was observed, particularly with the 2009 H1N1 pp at oseltamivir concentrations above 0.025muM. Further testing on two wild 2009 H1N1 virus strains, A/California/07/09 and A/Sichuan/1/09, as well as a seasonal flu virus, A/Baoan/51/2008, confirmed these findings. This article was published in Biochem Biophys Res Commun and referenced in Journal of Bioterrorism & Biodefense

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