alexa Ototoxicity of Burow solution on the guinea pig cochlea.


Otolaryngology: Open Access

Author(s): Sugamura M, Yamano T, Higuchi H, Takase H, Yoshimura H,

Abstract Share this page

Abstract PURPOSE OF THE STUDY: The aim of the present study was to evaluate the ototoxicity of Burow solution. PROCEDURES: Compound action potentials (CAPs) of the eighth nerve were measured before and 30 minutes after the application of the Burow solution in the middle ear cavity. RESULTS: Use of the original Burow solution (pH 3.5) for 30 minutes caused a significant reduction of click sounds. A 2-fold diluted Burow solution (pH 4.4) for 30 minutes caused no reduction in CAP threshold. Burow solution, pH adjusted to 4.5, caused no changes in CAP threshold at 30 minutes. At 24 hours, Burow solution (pH 3.5) caused complete abolition of CAP. CONCLUSIONS: Burow solution is ototoxic in the guinea pig when applied in the middle ear cavity for 30 minutes or longer. In the clinical settings, it is advisable to avoid allowing the solution to contact the round window for extended times. Copyright © 2012 Elsevier Inc. All rights reserved. This article was published in Am J Otolaryngol and referenced in Otolaryngology: Open Access

Relevant Expert PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version