Author(s): Masjedi MR, Tabarsi P, Chitsaz E, Baghaei P, Mirsaeidi M,
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Abstract BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) imposes a formidable burden on national health systems. There is still no consensus on the subject, with controversies regarding treatment protocols, treatment outcomes and the various treatment regimens. METHODS: The present study describes Iran's second national cohort for treatment of MDR-TB. The study comprised all documented MDR-TB cases in Iran referred to our centre during the period 2002-2006. All patients received a standardised second-line regimen consisting of ofloxacin, cycloserine, prothionamide and amikacin. Based on drug susceptibility testing results, ethambutol and pyrazinamide were added to the regimen. RESULTS: Forty-three patients diagnosed with MDR-TB, with a mean age of 44.38 +/- 19.05 years, received treatment; of these, 27 (62.8\%) were male. Twenty-three were (53.5\%) Iranians and the remainder were Afghans. All patients were acquired MDR-TB cases. Of the 43 cases, 25 (58.1\%) experienced severe clinically significant adverse effects; 29 (67.5\%) had a successful outcome and 14 (32.5\%) had a poor outcome (treatment failure in six [14\%] and death in eight [18.6\%]). Mortality was higher in Iranians (P = 0.039) and in patients whose initial regimen was changed due to adverse drug reactions (P = 0.01). CONCLUSION: Compared with previous studies, our study was able to obtain more favourable outcomes of MDR-TB treatment using a standardised regimen.
This article was published in Int J Tuberc Lung Dis
and referenced in Journal of Molecular Biomarkers & Diagnosis