alexa Overview of Taxol safety.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Onetto N, Canetta R, Winograd B, Catane R, Dougan M, , Onetto N, Canetta R, Winograd B, Catane R, Dougan M,

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Abstract The safety profile of Taxol administered intravenously as a single agent has been established based on the experience of 655 patients. Of these patients, 253 were treated in nine phase I studies, and 402 were treated in eight disease-oriented phase II studies. Myelosuppression, specifically neutropenia, was the dose-limiting toxicity in all studies conducted in patients with solid tumors. Neutropenia was schedule dependent and was less severe when Taxol was administered via a 3-hour infusion. Severe hypersensitivity reactions were controlled in the phase II program with a premedication regimen consisting of dexamethasone, an antihistamine, and an H2 blocker. Cardiovascular toxicities were minimal and do not indicate constant electrocardiographic monitoring during Taxol infusions. Peripheral neuropathy was usually mild to moderate and dose related; however, it rarely caused treatment discontinuation. Additional adverse events associated with Taxol include arthralgia/myalgia, mucositis, nausea and vomiting, and alopecia.
This article was published in J Natl Cancer Inst Monogr and referenced in Journal of Cancer Science & Therapy

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