Author(s): Pasupathi Palanisamy
The aim of this study was to investigate the predictive value of an oxidative stress, cardiac biomarkers and antioxidant status in acute myocardial infarction (AMI). The study population contained 100 subjects divided in two groups, 50 patients with AMI and equal number of age and sex matched healthy subjects were investigated. Lipid peroxidation was measured as thiobarbituric acid reactive substances (TBARS). TBARS, ceruloplasmin(Ce), total cholesterol(TC), triglyceride(Tg), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), creatin kinase (CK), creatine kinase-myoglobin binding (CK-MB), troponin T, troponin I, C-reactive protein (CRP), and brain natriuretic peptide (BNP) levels were found significantly high in patients with AMI as compared to healthy subjects but significantly decreased in HDL-cholesterol in AMI patients as compared to healthy controls. The activities of antioxidant (vitamin A (ï¿½-carotene), vitamin E, vitamin C, superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels were found significantly decreased in patients with AMI as compared to healthy subjects. AMI is associated with greater than normal lipid peroxidation and with an imbalance in antioxidants' status. In conclusion, our study shows a significantly increase in lipid peroxidation and cardiac biomarkers in the circulation of patients with acute myocardial infarction. A significant decrease level of HDL-C and antioxidant stats (both enzymic and non-enzymic) were observes only in AMI patients. Thus, our study indicates an imbalance between oxidant and antioxidant molecules in AMI. Therefore these biomarkers may be useful diagnosis of patients with AMI.