alexa Oxidative stress, DNA damage, and breast cancer.


Journal of Cancer Science & Therapy

Author(s): Kang DH

Abstract Share this page

Abstract Oxidative stress is a disturbance in the balance between the production of reactive oxygen species (ROS) and antioxidant defenses. It occurs when excessive production of ROS overwhelms the antioxidant defense system or when there is a significant decrease or lack of antioxidant defenses. Oxidative stress, in turn, is known to cause DNA damage and mutations of tumor suppressor genes that are critical initial events in carcinogenesis. Interestingly, early findings of the studies suggest that environmental factors, such as high psychological stress and poor nutritional profile (eg, low antioxidant and high fat intake), increase ROS production. Given that breast cancer is a complex disorder in which gene-environment interactions play a significant role in the development of cancer, oxidative stress may be an excellent model for exploring mechanisms mediating gene-environment interactions for nurse scientists and advanced practice nurses. Such investigations may help to suggest future strategies for nonpharmacological interventions for decreasing cancer risk.
This article was published in AACN Clin Issues and referenced in Journal of Cancer Science & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version