alexa P-304: Association of CYP1A1, ACE and p22phox polymorphisms with essential hypertension in postmenopausal women
Reproductive Medicine

Reproductive Medicine

Gynecology & Obstetrics

Author(s): Vasco Lanca, Constanca Coelho, Helena Moreira, Luis Sardinha, Paula Alcantara, Joao BrazNogueira

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The aim of this study was to determine the role of CYP1A1 T6325C, p22phox C242T and ACE I/D genotypes in HD in postmenopausal (PM) women. The studied population consisted of 96 normotensive postmenopausal women and 26 postmenopausal women with HD. CYP1A1 T6325C, p22phox C242T and ACE I/D were determined by PCR-RFLP and PCR. Cytochrome P4501A1 (CYP1A1) catalyses the hydroxilation of oestradiol and arachidonic acid (AA), producing vasoactive substances, rendering the CYP1A1 a candidate predisposition gene for HD. The D allele of the angiotensin converting enzyme (ACE) I/D polymorphism is a genetic risk factor for HD and is responsible for a higher ACE activity. Angiotensin II (Ang II) generated by ACE activates, among other actions, the first step of AA production. Ang II also activates a membrane NAD(P)H oxidase of which p22phox is an essential subunit, producing superoxide anions. The p22phox C242T gene polymorphism has been associated, in some populations, with several cardiovascular conditions, but this association remains controversial. PM women with the C allele of the CYP1A1 T6325C polymorphism, associated with a higher cytochrome P4501A1 activity, have an increased risk of HD (OR = 2.9, 95%, CI: 1.1-7.5). Women with both the C allele of the CYP1A1 T6325C and the D allele of the ACE I/D polymorphisms present an increased risk of HD (OR = 3.9, 95%, CI: 1.2-12.0). No differences were found regarding the p22phox C242T polymorphism. The C allele of CYP1A1 T6325C polymorphism is a risk factor for HD in postmenopausal women, either when this genotype is considered by itself or in association with the D allele of the ACE I/D polymorphism.

This article was published in Oxford Journals and referenced in Gynecology & Obstetrics

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