Author(s): Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A,
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Abstract Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
This article was published in Aging (Albany NY)
and referenced in Journal of Carcinogenesis & Mutagenesis