alexa Paediatric Castleman disease: report of seven cases and review of the literature.
Dermatology

Dermatology

Journal of Clinical & Experimental Dermatology Research

Author(s): Parez N, BaderMeunier B, Roy CC, Dommergues JP

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Abstract Castleman disease is a distinct lymphoproliferative disorder of unknown origin. Seven new cases in children are reported here and 76 cases from the paediatric literature are reviewed. The disease has been reported in 46 females and 37 males, their age ranging from 2 months to 17 years. The disease was localized in 72 cases and multicentric in 11 cases. The hyalinovascular type was more frequently encountered (54\%) than the plasma cell type (24\%). Laboratory abnormalities were more often associated with the plasma cell type and were mainly represented by anaemia and hypergammaglobulinaemia. Treatment of the localized tumour consisted of surgical excision, whereas treatment of the multicentric form was medical, comprising prednisone and other immunosuppressor drugs. The disease in the paediatric population seems to have a more favourable course than in adults. CONCLUSION: The paediatric features of the disease suggest that Castleman disease in this population could represent an earlier form of the pathology or even suggest a benign lymphoproliferative disorder.
This article was published in Eur J Pediatr and referenced in Journal of Clinical & Experimental Dermatology Research

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