Author(s): Oberpichler H, Sauer D, Rossberg C, Mennel HD, Krieglstein J
Abstract Share this page
Abstract We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.
This article was published in J Cereb Blood Flow Metab
and referenced in Biochemistry & Pharmacology: Open Access