alexa Parametric simulation of drug release from hydrogel-based matrices.


Industrial Engineering & Management

Author(s): Lamberti G

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Abstract OBJECTIVES: In this work a model recently proposed to describe the drug release from hydrogel-based matrices was applied to describe the fractional drug release from matrices based on hydroxypropylmethylcellulose (HPMC) and diclofenac. METHODS: The model, firstly proposed to describe the behaviour of systems based on HPMC and theophylline and a single set of preparation variables, is based on mass balances and transport phenomena evaluation and it was solved by an FEM-based numerical code. The experimental data on the HPMC-diclofenac matrices, taken from literature, have been obtained by varying the drug loading ratio, the compression force, the powder size of both the drug and the polymer. KEY FINDINGS: A good agreement between experimental data and model predictions, as calculated in the present work, was obtained without the use of any adjustable parameters. CONCLUSIONS: The predictive nature of the model has been confirmed, even changing the drug molecule and other preparative parameters. © 2011 The Author. JPP © 2011 Royal Pharmaceutical Society. This article was published in J Pharm Pharmacol and referenced in Industrial Engineering & Management

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