alexa Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles).
Materials Science

Materials Science

Journal of Nanomedicine & Biotherapeutic Discovery

Author(s): Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA

Abstract Share this page

Abstract Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analgesic effect. All controls, including a simple mixture of the three components (drugs, nanoparticles, and surfactant) mixed directly before i.v. injection, exhibited no effect. Analgesia was also prevented by pretreatment with naloxone. Fluorescent and electron microscopic studies indicated that the passage of the particle-bound drug occurred by phagocytic uptake of the polysorbate 80-coated nanoparticles by the brain blood vessel endothelial cells.
This article was published in Brain Res and referenced in Journal of Nanomedicine & Biotherapeutic Discovery

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • World Congress on Regulations of Nanotechnology
    July 31-August 01, 2017 Chicago, Illinois, USA
  • 19th Nano Congress for Next Generation
    August 31-September 01, 2017 Brussels,Belgium
  • International conference on Industrial Nanotechnology
    September 18-19, 2017 Jacksonville, Florida, USA
  • 15th World Medical Nanotechnology Congress & Expo
    October 18-19, 2017 Osaka, Japan
  • 22ndInternational Conference and Expo on Nanoscience and Molecular Nanotechnology
    Nov 13-14, 2017 Vienna, Austria
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords