alexa Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution.


Journal of Clinical & Cellular Immunology

Author(s): Simon MA, Chalifoux LV, Ringler DJ

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Abstract Since the original isolation of simian immunodeficiency virus (SIV) from a macaque with an AIDS-like disease, numerous studies have demonstrated the close biologic and genetic relationship of the SIVs to the HIVs. Probably most important, the clinical spectrum of disease associated with SIVmac/SIVsmm infection in rhesus monkeys is strikingly similar to AIDS in HIV-1-infected human beings. Herein are summarized the pathologic features of SIVmac-induced disease in a cohort of rhesus monkeys, with special reference to the role of infected macrophages in the development of AIDS-related manifestations. This article was published in AIDS Res Hum Retroviruses and referenced in Journal of Clinical & Cellular Immunology

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