Author(s): Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E,
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Abstract The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, cytotoxic cancer treatments have the potential to increase blood perfusion, thereby improving drug delivery.
This article was published in Nature
and referenced in Journal of Tissue Science & Engineering