alexa Pathology of ochratoxicosis A in young broiler chicks.


Journal of Clinical Toxicology

Author(s): Dwivedi P, Burns RB

Abstract Share this page

Abstract Ochratoxin A (OA), a potent nephrotoxin, was fed in the diet in sublethal concentrations (2 and 4 ppm) to broiler chicks for 20 days from hatch. Its effects on growth, relative organ size and histology of the liver, kidney and lymphoid organs were investigated. In young broiler chicks, OA caused a significant enlargement of the kidney, liver and proventriculus, whereas the thymus and bursa of Fabricius were reduced in size. It principally affected the proximal convoluted tubules of the kidney causing severe distension, enlargement and hypertrophy, and it also resulted in thickening of the glomerular basement membrane. In the liver, vacuolation and glycogen accumulation in the hepatocytes were seen. The toxin also caused regression of and a drastic reduction in the lymphoid cell population in the immunological organs. The toxicity of OA was found to be dose related.
This article was published in Res Vet Sci and referenced in Journal of Clinical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version