alexa PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice.


Journal of Clinical & Cellular Immunology

Author(s): Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F,

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Abstract Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune disease. Activation-induced cytidine deaminase-linked autoimmunity (aida) mice harbor a loss-of-function mutation in the gene encoding lymphocyte activation gene 3 (LAG-3), an inhibitory co-receptor. Although LAG-3 deficiency alone did not induce autoimmunity in nonautoimmune-prone mouse strains, it induced lethal myocarditis in BALB/c mice deficient for the gene encoding the inhibitory co-receptor programmed cell death 1 (PD-1). In addition, LAG-3 deficiency alone accelerated type 1 diabetes mellitus in nonobese diabetic mice. These results demonstrate that LAG-3 acts synergistically with PD-1 and/or other immunoregulatory genes to prevent autoimmunity in mice.
This article was published in J Exp Med and referenced in Journal of Clinical & Cellular Immunology

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