Author(s): Karwacz K, Arce F, Bricogne C, Kochan G, Escors D
Abstract Share this page
Abstract PD-1 engagement on the surface of effector T cells strongly suppresses their cytotoxic function, which constitutes a major obstacle for T cell-mediated anti-tumor activities. Surprisingly, PD-1 is strongly upregulated in T cells, engaging its ligand PD-L1 during antigen presentation. However, our recent published data may provide an explanation for this apparent contradiction.
This article was published in Oncoimmunology
and referenced in Journal of Clinical & Cellular Immunology