alexa PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy.


Journal of Clinical & Cellular Immunology

Author(s): Karwacz K, Arce F, Bricogne C, Kochan G, Escors D

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Abstract PD-1 engagement on the surface of effector T cells strongly suppresses their cytotoxic function, which constitutes a major obstacle for T cell-mediated anti-tumor activities. Surprisingly, PD-1 is strongly upregulated in T cells, engaging its ligand PD-L1 during antigen presentation. However, our recent published data may provide an explanation for this apparent contradiction.
This article was published in Oncoimmunology and referenced in Journal of Clinical & Cellular Immunology

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