alexa Pentalogy of Cantrell and associated midline anomalies: a possible ventral midline developmental field.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Carmi R, Boughman JA

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Abstract Five cases of the Pentalogy of Cantrell (PC), ascertained through the Baltimore-Washington population-based study of infants with congenital cardiovascular malformations, represent a regional prevalence of 5.5/1 million liveborn infants for this disorder. Three of these patients had cleft lip with or without palate. Review of the reported literature of the Pentalogy of Cantrell and various combinations of the anomalies within the spectrum of this pentad suggests that the PC defines a specific midline ventral developmental field. Cleft lip with or without cleft palate and encephalocele tend to specifically associate with ventral midline anomalies within the spectrum of PC. These associations might either illustrate the previously observed tendency of specific occurrence of certain combinations of midline defects or represent defined subunits of the midline developmental field. This article was published in Am J Med Genet and referenced in Journal of Addiction Research & Therapy

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