alexa Pentatricopeptide repeat proteins: a socket set for organelle gene expression.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Data Mining in Genomics & Proteomics

Author(s): SchmitzLinneweber C, Small I

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Abstract Pentatricopeptide repeat (PPR) proteins are RNA-binding proteins that are particularly prevalent in terrestrial plants. Although the PPR protein family was only recognized eight years ago, it is already clear that these proteins have a range of essential functions in post-transcriptional processes (including RNA editing, RNA splicing, RNA cleavage and translation) within mitochondria and chloroplasts. Several PPR proteins have been shown to act as fertility restorer genes in commercially important cytoplasmic male sterility systems. Here, we discuss several recent papers that cover their evolutionary history and molecular mode of action. We use these new data to propose hypotheses for their physiological roles that could explain why PPR proteins are so numerous in terrestrial plants. This article was published in Trends Plant Sci and referenced in Journal of Data Mining in Genomics & Proteomics

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