Author(s): Lennard KR, Tavassoli A
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Abstract Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
This article was published in Chemistry
and referenced in Biochemistry & Pharmacology: Open Access