alexa Percutaneous Penetration of Hydrocortisone With Urea


Journal of Clinical & Experimental Dermatology Research

Author(s): Robert J Feldmann, Howard I Maibach

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One percent14C-hydrocortisone acetate in a cream vehicle with and without 10% urea was applied to the ventral forearm of five adult male volunteers in a crossover experiment. Using the urinary recovery of14C as an index of penetration, the addition of urea to the cream increased penetration approximately twofold.

This article was published in Arch Dermatol and referenced in Journal of Clinical & Experimental Dermatology Research

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