alexa Peripheral neuropathy in selectively-inbred spontaneously diabetic rats: electrophysiological, morphometrical and freeze-replica studies.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Developing Drugs

Author(s): Yagihashi S, Tonosaki A, Yamada K, Kakizaki M, Goto Y, Yagihashi S, Tonosaki A, Yamada K, Kakizaki M, Goto Y

Abstract Share this page

Abstract Function and structure of peripheral nerves in selectively-inbred spontaneously diabetic rats (SDR) were quantitatively examined in order to clarify the relationship between these two changes. Electrophysiologically, SDR showed a significant decrease in motor nerve conduction velocity of the tail by 2 months of age. Thereafter, the conduction velocity was constantly lower in SDR than in age-matched control rats. Morphometrical analysis of peripheral nerves from light and electron micrographs could not yield any definite structural differences, except for a reduction in caliber of unmyelinated axons, between 2 month-old and age-matched controls, whereas an endoneurial space was widened in 3 month-old SDR as compared with those of controls. In contrast, loss of myelinated nerve fibers, a reduction in nerve fiber size and axonal size were apparent in 6 month-old SDR. By freeze-replica studies, neither any qualitative changes of intramembrane faces nor any quantitative differences in the density of intramembranous particles of internodal myelin and Schwann cell membranes were detected in 2 month-old SDR when compared with those in controls. The results suggested that the delayed nerve conduction velocity was most related to diabetic dysmetabolism and independent of the structural changes of peripheral nerves being in the course of distal axonopathy.
This article was published in Tohoku J Exp Med and referenced in Journal of Developing Drugs

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords