alexa Peroxisome Proliferator-Activated Receptor α Ligands Increase Lectin-Like Oxidized Low Density Lipoprotein Receptor-1 Expression in Vascular Endothelial Cells


Journal of Clinical & Experimental Ophthalmology

Author(s): Hayashida K, Kume N, Minami M, Kataoka H, Morimoto M

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Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a receptor for atherogenic oxidized LDL expressed in vascular endothelial cells, smooth muscle cells, and macrophages. Peroxiosme proliferator-activated receptors (PPARs) include subfamilies PPARα and PPARγ, which are expressed in endothelial cells and involved in transcriptional regulation of a large number of genes that affect lipoprotein and fatty acid metabolism as well as inflammation. We therefore explored the effects of PPARα and PPARγ ligands on expression of LOX-1. Treatment of cultured bovine aortic endothelial cells (BAECs) with PPARα ligands (fenofibrate and WY14643) remarkably upregulated LOX-1 expression, which was detected by western and northern blot analyses. LOX-1 promoter-reporter gene assay showed that PPARα ligands activate transcription of the LOX-1 gene. PPARγ ligands, in contrast, did not significantly affect LOX-1 expression in BAECs. PPARα appears to be a key regulator in promoting LOX-1 expression in BAECs. Upregulated expression of LOX-1 may modulate the catabolism of oxidized LDL and atherosclerotic progression.

This article was published in Annals of the New York Academy of Sciences and referenced in Journal of Clinical & Experimental Ophthalmology

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