Author(s): Anna Ewa Litwic, Melonie Kannamma Sriranganatha, Christopher John Edwards
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An ever increasing body of experimental evidence links the deregulation of signal transduction pathways in cells of the immune system, synovial tissue, articular cartilage and subchondral bone to the pathogenesis and progression of adult rheumatoid arthritis. In this regard, elevated levels, as well as a changing repertoire, of proinflammatory cytokines in the sera and synovial fluids of rheumatoid arthritis patients appear to deregulate activation of three signal transduction pathways, JAK/STAT, SAPK/MAPK and the PI3K/tensin homolog/Akt/mTOR pathways, which are critical to the homeostatic mechanism regulating cell survival and apoptosis.
This article was published in Int J ClinRheumatol
and referenced in Immunotherapy: Open Access