alexa Perspective: Deregulation of apoptosis in arthritis by altered signal transduction.
Immunology

Immunology

Immunotherapy: Open Access

Author(s): Anna Ewa Litwic, Melonie Kannamma Sriranganatha, Christopher John Edwards

Abstract Share this page

An ever increasing body of experimental evidence links the deregulation of signal transduction pathways in cells of the immune system, synovial tissue, articular cartilage and subchondral bone to the pathogenesis and progression of adult rheumatoid arthritis. In this regard, elevated levels, as well as a changing repertoire, of proinflammatory cytokines in the sera and synovial fluids of rheumatoid arthritis patients appear to deregulate activation of three signal transduction pathways, JAK/STAT, SAPK/MAPK and the PI3K/tensin homolog/Akt/mTOR pathways, which are critical to the homeostatic mechanism regulating cell survival and apoptosis. This article was published in Int J ClinRheumatol and referenced in Immunotherapy: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords