alexa Perspectives of zebrafish models of epilepsy: what, how and where next?
Biochemistry

Biochemistry

Biochemistry & Analytical Biochemistry

Author(s): Stewart AM, Desmond D, Kyzar E, Gaikwad S, Roth A,

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Abstract Epilepsy is a complex brain disorder with multiple underlying causes and poorly understood pathogenetic mechanisms. Animal models have been indispensable tools in experimental epilepsy research. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism to study various brain disorders. Seizure-like behavioral and neurophysiological responses can be evoked in larval and adult zebrafish by various pharmacological and genetic manipulations, collectively emphasizing the growing utility of this model for studying epilepsy. Here, we discuss recent developments in using zebrafish models to study the seizure-like behavior involved in epilepsy, outlining current challenges and strategies for further translational research in this field. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in Brain Res Bull and referenced in Biochemistry & Analytical Biochemistry

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