alexa Phage therapy: the peculiar kinetics of self-replicating pharmaceuticals.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Payne RJ, Phil D, Jansen VA

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Abstract The specter of antibiotic-resistant bacteria has provoked renewed interest in the possible use of bacteriophages to control bacterial infections. We argue that clinical application of phage therapy has been held back by a failure to appreciate the extent to which the pharmacokinetics of self-replicating agents differ from those of normal drugs. For self-replicating pharmaceutical agents, treatment outcome depends critically on various density-dependent thresholds, often with apparently paradoxical consequences. An ability to predict these thresholds and associated critical time points is a necessity if phage therapy is to become clinically practicable. This article was published in Clin Pharmacol Ther and referenced in Journal of Bioterrorism & Biodefense

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