alexa Pharmacokinetics of biosynthetic and pituitary human growth hormones in rats.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Jrgensen KD, Monrad JD, Brndum L, Dinesen B

Abstract Share this page

Abstract The pharmacokinetics of biosynthetic and pituitary human growth hormones (B-hGH and P-hGH) was compared in rats. Normal and hypophysectomized male and female rats were subcutaneously and intramuscularly injected with 100 micrograms/kg B-hGH and P-hGH and intravenously with 60 micrograms/kg B-hGH and P-hGH. A statistically significantly smaller distribution volume and a slower metabolic clearance rate (MCR) was found for B-hGH compared to P-hGH. A statistically significantly smaller distribution volume and MCR was found for hypophysectomized rats compared to normal rats. The plasma half lives were estimated to be about 3-7 min. (alpha 1/2) and 29 min. (beta 1/2). The plasma levels of hGH were higher after subcutaneous compared to intramuscular administration. The data imply that an extensive local degradation took place at the subcutaneous and intramuscular injection sites. Comparative tissue distribution studies were performed with radioiodinated B-hGH and P-hGH. No differences were observed between the growth hormones. It was found that most of the labelled TCA precipitable material was cleared through the liver. The females cleared relatively more through the liver than the males, while the males cleared relatively more through the kidneys.
This article was published in Pharmacol Toxicol and referenced in Journal of Clinical & Experimental Pharmacology

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]om

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords