Author(s): Koren G, Crean P, Goresky GV, Klein J, MacLeod SM, Koren G, Crean P, Goresky GV, Klein J, MacLeod SM
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Abstract Two cases of fentanyl anesthesia in children with renal diseases are described. In a case of end stage renal failure, the pharmacokinetic parameters during cardiac surgery were similar to 18 children from the same age group with normal renal function. In a case of Wilm's tumor, there was an unusually prolonged elimination half-life of fentanyl and smaller distribution volume as compared to pediatric parameters during fentanyl anesthesia.
This article was published in Res Commun Chem Pathol Pharmacol
and referenced in Journal of Forensic Research