alexa Pharmacokinetics of thiopental in caesarian section.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Christensen JH, Andreasen F, Jansen JA

Abstract Share this page

Abstract Anaesthesia for planned caesarian section in nine women was induced with an i.v. thiopental injection. The injection was stopped when the ciliary reflex disappeared. 250-300 mg was given over 60-85 seconds. The concentration of thiopental in peripheral venous blood 20 s after the disappearance of the ciliary reflex varied from 4.3 to 33.7 micrograms/ml. The simultaneously obtained concentrations at delivery (11-25 min after the start of the induction) were 1.7-6.0 micrograms/ml in venous blood from the mothers and 1.3-5.5 micrograms/ml in cord vein blood. In two of the newborns, the Apgar scores were 8 and 9, in the other seven it was 10. The baby with Apgar score 8 was delivered after 25 min and had a concentration in cord vein blood of 3.5 micrograms/ml. The decline in the concentration of thiopental in the venous blood of the mothers was described by a three-compartment open model. The terminal half-life was relatively short, between 91 and 595 min. The blood levels of thiopental in the newborns were followed for 22-33 h. The terminal half-lives in the babies ranged from 616 to 2560 min.
This article was published in Acta Anaesthesiol Scand and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords