Author(s): Christensen JH, Andreasen F, Jansen JA
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Abstract Anaesthesia for planned caesarian section in nine women was induced with an i.v. thiopental injection. The injection was stopped when the ciliary reflex disappeared. 250-300 mg was given over 60-85 seconds. The concentration of thiopental in peripheral venous blood 20 s after the disappearance of the ciliary reflex varied from 4.3 to 33.7 micrograms/ml. The simultaneously obtained concentrations at delivery (11-25 min after the start of the induction) were 1.7-6.0 micrograms/ml in venous blood from the mothers and 1.3-5.5 micrograms/ml in cord vein blood. In two of the newborns, the Apgar scores were 8 and 9, in the other seven it was 10. The baby with Apgar score 8 was delivered after 25 min and had a concentration in cord vein blood of 3.5 micrograms/ml. The decline in the concentration of thiopental in the venous blood of the mothers was described by a three-compartment open model. The terminal half-life was relatively short, between 91 and 595 min. The blood levels of thiopental in the newborns were followed for 22-33 h. The terminal half-lives in the babies ranged from 616 to 2560 min.
This article was published in Acta Anaesthesiol Scand
and referenced in Pharmaceutica Analytica Acta