alexa Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Yates CM, Calder PC, Ed Rainger G

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Abstract Omega-3 (n-3) polyunsaturated fatty acids (n-3 PUFAs) have well documented anti-inflammatory properties, and consequently therapeutic potential in chronic inflammatory diseases. Here we discuss the effects of n-3 PUFAs on various inflammatory pathways and how this leads to alterations in the function of inflammatory cells, most importantly endothelial cells and leukocytes. Strong evidence indicates n-3 PUFAs are beneficial as a dietary supplement in certain diseases such as rheumatoid arthritis; however for other conditions such as asthma, the data are less robust. A clearer understanding of the pharmacology of n-3 PUFAs will help to establish targets to modulate chronic inflammatory diseases. Copyright © 2013 Elsevier Inc. All rights reserved. This article was published in Pharmacol Ther and referenced in Journal of Addiction Research & Therapy

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