alexa Phase II trial design with Bayesian adaptive randomization and predictive probability.
Mathematics

Mathematics

Journal of Biometrics & Biostatistics

Author(s): Yin G, Chen N, Lee JJ

Abstract Share this page

Abstract We propose a randomized phase II clinical trial design based on Bayesian adaptive randomization and predictive probability monitoring. Adaptive randomization assigns more patients to a more efficacious treatment arm by comparing the posterior probabilities of efficacy between different arms. We continuously monitor the trial by using the predictive probability. The trial is terminated early when it is shown that one treatment is overwhelmingly superior to others or that all the treatments are equivalent. We develop two methods to compute the predictive probability by considering the uncertainty of the sample size of the future data. We illustrate the proposed Bayesian adaptive randomization and predictive probability design by using a phase II lung cancer clinical trial, and we conduct extensive simulation studies to examine the operating characteristics of the design. By coupling adaptive randomization and predictive probability approaches, the trial can treat more patients with a more efficacious treatment and allow for early stopping whenever sufficient information is obtained to conclude treatment superiority or equivalence. The design proposed also controls both the type I and the type II errors and offers an alternative Bayesian approach to the frequentist group sequential design.
This article was published in J R Stat Soc Ser C Appl Stat and referenced in Journal of Biometrics & Biostatistics

Relevant Expert PPTs

Relevant Speaker PPTs

  • Yuan Ma
    Salt sales survey: a simplified, cost-effective method to evaluate population salt reduction programmes-a cluster randomised trial
    PPT Version | PDF Version
  • Narender Goel
    Vascular Access Placement in Patients with Incident CKD Stage 4 and 5 attending an Inner City Nephrology Clinic: A Cohort Study and Survey of Providers
    PPT Version | PDF Version
  • Barbara C Wallace
    E-HEALTH Interventions Using Avatar Videos to Address Health Disparities: Results of Online Survey Evaluations Conducted by the Research Group on Disparities in Health
    PPT Version | PDF Version
  • Sayan Bhattacharya
    Hydrological, agricultural and environmental surveys of Lava and Rishop: Two ecologically important hamlets of North Bengal, India
    PPT Version | PDF Version
  • Arya Payan
    Barriers to Papanicolaou screening among HIV-infected women: A cross sectional survey
    PPT Version | PDF Version
  • Md Bahadur Badsha
    Integration of omics into metabolic flux distribution by complementary elementary mode analysis for large-scale metabolic networks
    PDF Version

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords