Author(s): Yamamoto KK, Gonzalez GA, Biggs WH rd, Montminy MR
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Abstract A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.
This article was published in Nature
and referenced in Journal of Genetic Syndromes & Gene Therapy