Author(s): Bushara KO, Goldstein SR, Grimes GJ Jr, Burstein AH, Hallett M, Bushara KO, Goldstein SR, Grimes GJ Jr, Burstein AH, Hallett M
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Abstract 1-Octanol (an 8-C alcohol currently used as a food-flavoring agent) is known to inhibit tremor in essential tremor (ET) animal models at a much lower dose than ethyl alcohol. The authors conducted a randomized, placebo-controlled pilot trial of a single oral dose of 1 mg/kg of 1-octanol in 12 patients with ET. No significant side effects or signs of intoxication were observed. 1-Octanol significantly decreased tremor amplitude for up to 90 minutes. The results suggest 1-octanol as a well-tolerated and safe potential treatment for ET. Further trials are warranted.
This article was published in Neurology
and referenced in Journal of Multiple Sclerosis