Author(s): Qiu HY, Guo C, Cheng XW, Huang Y, Xiong ZQ,
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Abstract To generate temporally controlled inactivation or activation of interested genes in Pitx3-expressing cells, the tamoxifen-inducible form of Cre, CreER(T2), was inserted into the Pitx3 locus of a mouse BAC clone. Following a single dose of tamoxifen, Cre activity in Pitx3-CreER(T2) transgenic mice was observed in the ocular lens and skeletal muscles but not in the central nervous system at various embryonic stages. This mouse line provides a reagent for driving inducible Cre-dependent recombination in the lens and skeletal muscles during embryonic development. (c) 2008 Wiley-Liss, Inc.
This article was published in Genesis
and referenced in Advancements in Genetic Engineering