alexa PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein.
Biochemistry

Biochemistry

Biochemistry & Physiology: Open Access

Author(s): Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuisen B,

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Abstract A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene (PKD2) segregated with the disease in three PKD2 families. The predicted 968-amino acid sequence of the PKD2 gene product has six transmembrane spans with intracellular amino- and carboxyl-termini. The PKD2 protein has amino acid similarity with PKD1, the Caenorhabditis elegans homolog of PKD1, and the family of voltage-activated calcium (and sodium) channels, and it contains a potential calcium-binding domain.
This article was published in Science and referenced in Biochemistry & Physiology: Open Access

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