alexa Placental barrier breakage in preeclampsia: ultrastructural evidence.


Journal of Blood Disorders & Transfusion

Author(s): de Luca Brunori I, Battini L, Brunori E, Lenzi P, Paparelli A,

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Abstract OBJECTIVE: It is known that the placenta acts as an immunological barrier between the mother and fetal "graft" allowing two antigenically different organisms to tolerate one another. Preeclampsia may be considered as a fetal rejection consequent to severe damage at placental endothelial and syncytiotrophoblast level. In order to verify this placental barrier damage we undertook the present study by electron microscopy. STUDY DESIGN: 14 placentae from preeclaptic women, and the same number of placentae from healthy controls were examined. RESULTS: The results showed that endothelial cells from preeclamptic placentae express various and severe alterations, consisting of swollen and bulbous cytoplasm, degenerated inter-endothelial junctions with consequent crossing of fetal blood cells outside the vessels. CONCLUSIONS: These lesions could be the ultrastructural evidence of the placental barrier breakage leading to rejective reaction we presumed to be basis of preeclampsia. This article was published in Eur J Obstet Gynecol Reprod Biol and referenced in Journal of Blood Disorders & Transfusion

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