alexa Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): Ahnstrm J, Gottster A, Lindblad B, Dahlbck B

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Abstract OBJECTIVES: Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA. DESIGN AND METHODS: Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population. RESULTS: AAA patients had lower apolipoprotein levels, as compared to healthy individuals: apoA-I, 1.62 vs. 2.08 g/L; apoB, 0.91 vs. 1.04 g/L; apoM, 0.72 vs. 0.91 mumol/L (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95\% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively. CONCLUSIONS: ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. This article was published in Clin Biochem and referenced in Journal of Proteomics & Bioinformatics

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