alexa Plasma homocysteine levels and vitamin B status in patients with Pseudoexfoliation syndrome.
Ophthalmology

Ophthalmology

Journal of Clinical & Experimental Ophthalmology

Author(s): Saricaoglu MS, Karakurt A, Sengun A, Hasiripi H

Abstract Share this page

Abstract OBJECTIVE: To determine and compare the plasma levels of homocysteine and vitamin B (B6, B12 and folate) in patients with Pseudoexfoliation syndrome (PEXS), pseudoexfoliation glaucoma (PEXG), retinal vein occlusion with pseudoexfoliation (PEX+RVO) and in normal individuals. METHODS: The current study was conducted in the Third Eye Clinic, Ankara Numune Training and Research Hospital, Turkey, between August 2004 and February 2005. Twenty cases with PEXS (Group 1), 20 cases with PEXG (Group 2), 16 cases with PEX+RVO (central or branch retinal vein occlusion) (Group 3) and 20 normal individuals (control group) were included in the study. Those who use vitamin supplements or drugs affecting the plasma homocysteine levels were excluded from the study. RESULTS: Plasma homocysteine levels were 17.6+/-4.4 mmol/l in Group 1, 18.5+/-4.5 mmol/l in Group 2, 22.2+/-6.0 mmol/l in Group 3, and 14.0+/-3.1 mmol/l in the control group. It was highest in Group 3 (p<0.001). The ratio of hyperhomocysteinemia was calculated as 35\% (Group 1), 45\% (Group 2), 68.7\% (Groups 3) and 15\% (control). These values were statistically higher in the groups with PEXS than in the control group (p=0.009). We did not find any statistically significant difference between the groups with respect to the levels of vitamin B6 and B12 (p>0.05), but the level of folate was lowest in Group 3 (p<0.001). CONCLUSION: Hyperhomocysteinemia is a risk factor for thromboembolic vasculopathy in patients with PEXS and PEXG. Therefore, vitamin B supplementation should be considered in these patients when hyperhomocysteinemia is detected.
This article was published in Saudi Med J and referenced in Journal of Clinical & Experimental Ophthalmology

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

agriaquaculture@omicsonline.com

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

biochemjournals@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

chemistryjournals@omicsonline.com

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

clinicaljournals@omicsonline.com

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

engineeringjournals@omicsonline.com

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

nutritionjournals@omicsonline.com

1-702-714-7001Extn: 9042

General Science

Andrea Jason

generalscience@omicsonline.com

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

geneticsmolbio@omicsonline.com

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immunomicrobiol@omicsonline.com

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

nursinghealthcare@omicsonline.com

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

medicaljournals@omicsonline.com

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuropsychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

pharmajournals@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords