alexa Plasma levels and pharmacokinetics of ethynyl estrogens in various populations. I. Ethynylestradiol.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Goldzieher JW, Dozier TS, de la Pena A

Abstract Share this page

Abstract PIP: A study to determine the pharmacokinetics of single doses of ethynylestradiol (EE) of 35-100 ug administered to a total of 98 women in the United States, Thailand, Nigeria, Sri Lanka, and Singapore. After EE ingestion, plasma samples were collected at various intervals with 65\% of U.S. patients exhibiting peak plasma EE levels between 60-90 minutes, and 2/3 showed detectable EE levels at 24 hours using 50-80 ug doses. To assess within-subject variation and range of variation between individuals, subjects in Palo Alto using 35 ug doses were tested twice showing a variation within subjects of 51.8\% and between subjects was 119\%. In Tucson, subjects using 100 ug EE doses showed a within-subject variation of 13.5\% and between subjects was 37\%. Absorption phase half-life ranged from 14-22 minutes, distribution phase varied from 1-3 hours, and the elimination half life ranged from 6-14 hours. Nigeria indicated the lowest plasma EE levels while Thailand had the highest levels even when body surface differences were accounted for. Dietary differences may cause differences in drug absorption; in addition, differences in relative muscle/fat ratios could effect storage and metabolism.
This article was published in Contraception and referenced in Journal of Bioequivalence & Bioavailability

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords