Author(s): Ramesh G, Berg A, Jayakumar C
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Abstract CONTEXT: The axon guidance cues netrin-1 is a secreted protein overexpressed in many different cancer tissues. OBJECTIVES: To determine whether plasma netrin-1 can be used as a diagnostic biomarker of human cancer. MATERIALS AND METHODS: A total of 300 cancer plasma samples from breast, renal, prostate, liver, meningioma, pituitary adenoma, glioblastoma, lung, pancreatic and colon cancer patients were compared against 138 control plasma samples. Netrin-1 levels were quantified by ELISA and immunohistochemistry. RESULTS: Plasma netrin-1 levels were significantly increased in breast, renal, prostate, liver, meningioma, pituitary adenoma, and glioblastoma cancers as compared to control samples. DISCUSSION AND CONCLUSION: Our results suggest that plasma netrin-1 can be used as a diagnostic biomarker for many human cancers.
This article was published in Biomarkers
and referenced in Journal of Vascular Medicine & Surgery