alexa Plasma renin activity, angiotensin II, and aldosterone during intense heat stress.
Clinical Sciences

Clinical Sciences

Cardiovascular Pharmacology: Open Access

Author(s): Kosunen KJ, Pakarinen AJ, Kuoppasalmi K, Adlercreutz H, Kosunen KJ, Pakarinen AJ, Kuoppasalmi K, Adlercreutz H

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Abstract Plasma renin activity (PRA), angiotensin II, and aldosterone levels, arterial blood pressure, and heart rate of six male students were investigated during and after heat stress in a sauna bath. Increased PRA, angiotensin II, and aldosterone levels were found both during and after sauna. The greatest mean increases in PRA (94.9 +/- 10.4\% SE, P less than 0.005) and angiotensin II (196 +/- 54.7\% SE, P less than 0.02) were observed at the end of the heat stress (at 20 min), and that in plasma aldosterone (505 +/- 209\% SE, P less than 0.02) 30 min after the sauna. The heart rate roughly doubled during the heat stress and there was a transient increase followed by a decrease in systolic blood pressure and a decrease in diastolic blood pressure. This study demonstrates that intense heat stress can cause remarkable changes in the three main components of the renin-angiotensin-aldosterone system.
This article was published in J Appl Physiol and referenced in Cardiovascular Pharmacology: Open Access

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