alexa Plasma resistin levels in asthmatics as a marker of disease state.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Larochelle J, Freiler J, Dice J, Hagan L

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Abstract BACKGROUND: Resistin is a protein produced by adipocytes and circulating macrophages that has been found to be associated with inflammatory states. OBJECTIVE: To determine the levels of resistin in relation to asthma disease state and severity, we investigated a cohort of adult patients with asthma. METHODS: A cohort of moderate to severe persistent asthma patients and control patients were recruited and underwent fasting labs to evaluate levels of serum glucose, C-reactive protein (CRP), and resistin. RESULTS: No significant differences were found between the control and asthma group with respect to serum CRP at 0.78 +/- 0.60 mg/dL and 0.48 +/- 0.60 mg/dL, (p < 0.36) or glucose at 92.2 +/- 11.9 mg/dL and 89.5 +/- 7.2 mg/dL, (p < 0.084), respectively (mean +/- SD). However, plasma resistin levels were found to be significantly elevated in asthma patients, 186 ng/mL (95\%CI 169-202) compared with control patients 121 ng/mL (95\%CI 90.4-151), (p < 0.005). CONCLUSIONS: Patients with asthma were found to have higher levels of resistin, and resistin levels were increased with disease severity in the asthma cohort. This article was published in J Asthma and referenced in Journal of Clinical & Cellular Immunology

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