Author(s): Li HM, Zhang TP, Leng RX, Li XP, Li XM, , Li HM, Zhang TP, Leng RX, Li XP, Li XM, , Li HM, Zhang TP, Leng RX, Li XP, Li XM, , Li HM, Zhang TP, Leng RX, Li XP, Li XM,
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Abstract BACKGROUND AND AIMS: Currently published data regarding the relationship between plasma/serum leptin levels and systemic lupus erythematosus (SLE) are contradictory. To derive a more precise evaluation of this relationship, a meta-analysis was performed. METHODS: Published literature from PubMed, Embase and Cochrane Library were obtained. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95\% confidence interval (CI) was calculated by fixed-effects or random-effect model analysis. Heterogeneity among studies was estimated using the Cochran Q and I(2) statistics. RESULTS: A total of 11 studies including 868 SLE patients and 591 controls were finally included in the meta-analysis. No significant differences in plasma/serum leptin levels was found between SLE patients and healthy controls when all studies were pooled into the meta-analysis (pooled SMD = 0.269, 95\% CI = -0.188 to 0.726). However, subgroup analyses showed that SLE patients from an Asian population, age ≥40 years and BMI <25 had higher plasma/serum leptin levels when compared with controls. CONCLUSION: There is no significant difference in plasma/serum leptin levels between the entire group of SLE patients and controls. However, plasma/serum leptin levels are significantly higher in the subgroup of SLE patients from an Asian population ≥40 years of age and with a BMI <25. Copyright © 2015 IMSS. Published by Elsevier Inc. All rights reserved.
This article was published in Arch Med Res
and referenced in Lupus: Open Access