alexa Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease.


Journal of Biometrics & Biostatistics

Author(s): Michelakakis H, Spanou C, Kondyli A, Dimitriou E, Van Weely S,

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Abstract Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 x the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.
This article was published in Biochim Biophys Acta and referenced in Journal of Biometrics & Biostatistics

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