Author(s): Amaratunga C, Witkowski B, Dek D, Try V, Khim N,
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Abstract Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early ring stage of parasite development and that a genetically admixed population contains subsets of parasites with normal or reduced ART sensitivity. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
This article was published in Antimicrob Agents Chemother
and referenced in Malaria Control & Elimination