alexa Pneumothorax as a first manifestation of sarcoidosis.


Journal of General Practice

Author(s): Froudarakis ME, Bouros D, Voloudaki A, Papiris S, Kottakis Y, , Froudarakis ME, Bouros D, Voloudaki A, Papiris S, Kottakis Y,

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Abstract Pneumothorax is a rare manifestation of sarcoidosis, occurring usually late in the course of the disease. We report five cases of pneumothorax as a presenting manifestation of sarcoidosis. In two patients, thoracotomy showed extensive pleural infiltration by noncaseating granulomas. High-resolution CT scans showed cavitated subpleural nodules and subpleural bullae in one case. These findings support that necrosis of subpleural granulomas or rupture of a subpleural bullae, or both, are the mechanisms of pneumothorax in sarcoidosis. Three patients with a lung function impairment were treated with oral corticosteroids. One nontreated patient died due to progression of the disease.
This article was published in Chest and referenced in Journal of General Practice

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